Compounds
| ID | Spectrum Quality | Annotated Name |
|---|
COMPOUND NPA008640
PROPERTIES
| NPAID | NPA008640 |
|---|---|
| CLUSTER ID | 739 |
| NODE ID | 645 |
| NAME | Thailanstatin A |
| FORMULA | C28H41NO9 |
| MOLECULAR WEIGHT (Da) | 535.6340 |
| ACCURATE MASS (Da) | 535.2781 |
| ORIGIN ORGANISM TYPE | Bacterium |
| ORIGIN GENUS | Burkholderia |
| ORIGIN SPECIES | sp. FERM BP-3421 |
| InChIKey | GJKQDOMCDFJANR-FUDLAKRJSA-N |
| InChI | InChI=1S/C28H41NO9/c1-16(7-10-24-27(34)28(15-35-28)14-21(38-24)13-26(32)33)6-9-23-17(2)12-22(19(4)37-23)29-25(31)11-8-18(3)36-20(5)30/h6-8,10-11,17-19,21-24,27,34H,9,12-15H2,1-5H3,(H,29,31)(H,32,33)/b10-7+,11-8-,16-6+/t17-,18-,19+,21+,22+,23-,24+,27+,28+/m0/s1 |
| SMILES | C[C@H]1C[C@H]([C@H](O[C@H]1C/C=C(\C)/C=C/[C@@H]2[C@H]([C@@]3(C[C@H](O2)CC(=O)O)CO3)O)C)NC(=O)/C=C\[C@H](C)OC(=O)C |
ORIGINAL ISOLATION REFERENCE
| CITATION | Liu, Xiangyang; Biswas, Sreya; Berg, Michael G.; Antapli, Christopher M.; Xie, Feng; Wang, Qi; Tang, Man-Cheng; Tang, Gong-Li; Zhang, Lixin; Dreyfuss, Gideon; Cheng, Yi-Qiang Genomics-guided discovery of thailanstatins A, B, and C as pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43 Journal of Natural Products 2013 76 (4) 685-693. | ||
|---|---|---|---|
| DOI | 10.1021/np300913h | PMID | 23517093 |
SYNTHESES
| CITATION 1 | Nicolaou KC; Rhoades D; Lamani M; Pattanayak MR; Kumar SM Total Synthesis of Thailanstatin A. Journal of the American Chemical Society 2016 138 (24) 7532-7535. DOI: 10.1021/jacs.6b04781 PMID: 27266914 | ||
|---|---|---|---|
