Compounds
| ID | Spectrum Quality | Annotated Name |
|---|
COMPOUND NPA006938
PROPERTIES
| NPAID | NPA006938 |
|---|---|
| CLUSTER ID | 3161 |
| NODE ID | 2408 |
| NAME | Telomestatin |
| FORMULA | C26H14N8O7S |
| MOLECULAR WEIGHT (Da) | 582.5140 |
| ACCURATE MASS (Da) | 582.0706 |
| ORIGIN ORGANISM TYPE | Bacterium |
| ORIGIN GENUS | Streptomyces |
| ORIGIN SPECIES | anulatus |
| InChIKey | YVSQVYZBDXIXCC-INIZCTEOSA-N |
| InChI | InChI=1S/C26H14N8O7S/c1-9-17-24-30-14(6-39-24)21-28-12(4-37-21)19-27-11(3-35-19)20-29-13(5-36-20)22-31-15(7-38-22)26-32-16(8-42-26)23-33-18(10(2)40-23)25(34-17)41-9/h3-7,16H,8H2,1-2H3/t16-/m0/s1 |
| SMILES | CC1=C2N=C(O1)C1=C(C)OC(=N1)[C@@H]1CSC(=N1)C1=COC(=N1)C1=COC(=N1)C1=COC(=N1)C1=COC(=N1)C1=COC2=N1 |
ORIGINAL ISOLATION REFERENCE
| CITATION | Shin-ya, Kazuo; Wierzba, Konstanty; Matsuo, Ken-ichi; Ohtani, Toshio; Yamada, Yuji; Furihata, Kazuo; Hayakawa, Yoichi; Seto, Haruo Telomestatin, a Novel Telomerase Inhibitor from Streptomyces anulatus Journal of the American Chemical Society 2001 123 (6) 1262-1263. | ||
|---|---|---|---|
| DOI | 10.1021/ja005780q | PMID | 11456694 |
SYNTHESES
| CITATION 1 | Doi T; Yoshida M; Shin-ya K; Takahashi T Total synthesis of (R)-telomestatin. Organic Letters 2006 8 (18) 4165-7. DOI: 10.1021/ol061793i PMID: 16928100 | ||
|---|---|---|---|
| CITATION 2 | Doi T; Shibata K; Yoshida M; Takagi M; Tera M; Nagasawa K; Shin-ya K; Takahashi T (S)-stereoisomer of telomestatin as a potent G-quadruplex binder and telomerase inhibitor. Organic & Biomolecular Chemistry 2011 9 (2) 387-93. DOI: 10.1039/c0ob00513d PMID: 20967317 | ||
REVISIONS
| VERSION | SMILES | CITATION | ||
|---|---|---|---|---|
| Original Isolation | CC1=C2C3=NC(=C(O3)C)C4=NC(=CO4)C5=NC(=CO5)C6=NC(=CO6)C7=NC(=CO7)C8=NC(=CO8)C9=NC(CS9)C(=N2)O1 | Shin-ya, Kazuo; Wierzba, Konstanty; Matsuo, Ken-ichi; Ohtani, Toshio; Yamada, Yuji; Furihata, Kazuo; Hayakawa, Yoichi; Seto, Haruo Telomestatin, a Novel Telomerase Inhibitor from Streptomyces anulatus Journal of the American Chemical Society 2001 123 (6) 1262-1263. DOI: 10.1021/ja005780q PMID: 11456694 | ||
| 2 | CC1=C2N=C(O1)C1=C(C)OC(=N1)[C@@H]1CSC(=N1)C1=COC(=N1)C1=COC(=N1)C1=COC(=N1)C1=COC(=N1)C1=COC2=N1 | Doi T; Yoshida M; Shin-ya K; Takahashi T Total synthesis of (R)-telomestatin. Organic Letters 2006 8 (18) 4165-7. DOI: 10.1021/ol061793i PMID: 16928100 | ||
