Compounds
| ID | Spectrum Quality | Annotated Name |
|---|
COMPOUND NPA019793
PROPERTIES
| NPAID | NPA019793 |
|---|---|
| CLUSTER ID | 1054 |
| NODE ID | 11 |
| NAME | Lynamicin D |
| FORMULA | C24H17Cl2N3O4 |
| MOLECULAR WEIGHT (Da) | 482.3230 |
| ACCURATE MASS (Da) | 481.0596 |
| ORIGIN ORGANISM TYPE | Bacterium |
| ORIGIN GENUS | Actinomyces |
| ORIGIN SPECIES | nPS12745 |
| InChIKey | YYBKJQDTRQASSS-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H17Cl2N3O4/c1-32-23(30)21-19(15-9-27-17-5-3-11(25)7-13(15)17)20(22(29-21)24(31)33-2)16-10-28-18-6-4-12(26)8-14(16)18/h3-10,27-29H,1-2H3 |
| SMILES | COC(=O)C1=C(C(=C(N1)C(=O)OC)C2=CNC3=C2C=C(C=C3)Cl)C4=CNC5=C4C=C(C=C5)Cl |
ORIGINAL ISOLATION REFERENCE
| CITATION | McArthur, Katherine A.; Mitchell, Scott S.; Tsueng, Ginger; Rheingold, Arnold; White, Donald J.; Grodberg, Jennifer; Lam, Kin S.; Potts, Barbara C. M. Lynamicins A-E, chlorinated bisindole pyrrole antibiotics from a novel marine actinomycete Journal of Natural Products 2008 71 (10) 1732-1737. | ||
|---|---|---|---|
| DOI | 10.1021/np800286d | PMID | 18842058 |
SYNTHESES
| CITATION 1 | Sigala I; Ganidis G; Thysiadis S; Zografos AL; Giannakouros T; Sarli V; Nikolakaki E Lynamicin D an antimicrobial natural product affects splicing by inducing the expression of SR protein kinase 1. Bioorganic and Medicinal Chemistry 2017 25 (5) 1622-1629. DOI: 10.1016/j.bmc.2017.01.025 PMID: 28139279 | ||
|---|---|---|---|
