Compounds
| ID | Spectrum Quality | Annotated Name |
|---|
COMPOUND NPA018275
PROPERTIES
| NPAID | NPA018275 |
|---|---|
| CLUSTER ID | 4876 |
| NODE ID | 141 |
| NAME | Humidimycin |
| FORMULA | C98H132N22O27S4 |
| MOLECULAR WEIGHT (Da) | 2178.5290 |
| ACCURATE MASS (Da) | 2176.8515 |
| ORIGIN ORGANISM TYPE | Bacterium |
| ORIGIN GENUS | Streptomyces |
| ORIGIN SPECIES | humidus |
| InChIKey | KEGZLFHRZXUETN-KUYIIAQISA-N |
| InChI | InChI=1S/C98H132N22O27S4/c1-11-50(7)80-95(143)102-41-75(125)107-68(43-121)91(139)116-71-46-150-151-47-72(94(142)112-64(33-55-23-17-14-18-24-55)88(136)115-67(98(146)147)36-58-35-57-25-19-20-26-60(57)105-58)117-96(144)79(49(5)6)119-97(145)81(51(8)12-2)120-83(131)53(10)104-86(134)62(34-56-27-29-59(122)30-28-56)106-74(124)40-101-85(133)69-44-148-149-45-70(92(140)110-61(31-48(3)4)84(132)100-42-77(127)118-80)108-73(123)37-65(113-90(138)66(38-78(128)129)114-93(71)141)89(137)111-63(32-54-21-15-13-16-22-54)87(135)103-52(9)82(130)99-39-76(126)109-69/h13-30,35,48-53,61-72,79-81,105,121-122H,11-12,31-34,36-47H2,1-10H3,(H,99,130)(H,100,132)(H,101,133)(H,102,143)(H,103,135)(H,104,134)(H,106,124)(H,107,125)(H,108,123)(H,109,126)(H,110,140)(H,111,137)(H,112,142)(H,113,138)(H,114,141)(H,115,136)(H,116,139)(H,117,144)(H,118,127)(H,119,145)(H,120,131)(H,128,129)(H,146,147)/t50-,51-,52-,53-,61-,62+,63-,64-,65-,66-,67-,68-,69-,70+,71+,72+,79-,80-,81-/m0/s1 |
| SMILES | CC[C@H](C)[C@H]1C(=O)NCC(=O)N[C@H](C(=O)N[C@@H]2CSSC[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)CNC(=O)[C@@H]3CSSC[C@H](C(=O)N[C@H](C(=O)NCC(=O)N1)CC(C)C)NC(=O)C[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N3)C)CC4=CC=CC=C4)NC(=O)[C@@H](NC2=O)CC(=O)O)CC5=CC=C(C=C5)O)C)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](CC6=CC=CC=C6)C(=O)N[C@@H](CC7=CC8=CC=CC=C8N7)C(=O)O)CO |
ORIGINAL ISOLATION REFERENCE
| CITATION | Valiante, Vito; Monteiro, Maria Cândida; Martín, Jesús; Altwasser, Robert; Aouad, Noureddine El; González, Ignacio; Kniemeyer, Olaf; Mellado, Emilia; Palomo, Sara; De Pedro, Nuria; Pérez-Victoria, Ignacio; Tormo, José R.; Vicente, Francisca; Reyes, Fernando; Genilloud, Olga; Brakhage, Axel A. Hitting the caspofungin salvage pathway of human-pathogenic fungi with the novel lasso peptide humidimycin (MDN-0010) Antimicrobial Agents and Chemotherapy 2015 59 (9) 5145-5153. | ||
|---|---|---|---|
| DOI | 10.1128/aac.00683-15 | PMID | 26055366 |
