Compounds
| ID | Spectrum Quality | Annotated Name |
|---|
COMPOUND NPA017297
PROPERTIES
| NPAID | NPA017297 |
|---|---|
| CLUSTER ID | 5832 |
| NODE ID | 4108 |
| NAME | TMC-205 |
| FORMULA | C14H13NO2 |
| MOLECULAR WEIGHT (Da) | 227.2630 |
| ACCURATE MASS (Da) | 227.0946 |
| ORIGIN ORGANISM TYPE | Bacterium |
| ORIGIN GENUS | Unknown-bacterium |
| ORIGIN SPECIES | sp. strain |
| InChIKey | DGRQZYNJXNNHBY-ONEGZZNKSA-N |
| InChI | InChI=1S/C14H13NO2/c1-9(2)3-4-10-5-6-11-12(14(16)17)8-15-13(11)7-10/h3-8,15H,1H2,2H3,(H,16,17)/b4-3+ |
| SMILES | CC(=C)/C=C/C1=CC2=C(C=C1)C(=CN2)C(=O)O |
ORIGINAL ISOLATION REFERENCE
| CITATION | SAKURAI, MASAAKI; KOHNO, JUN; NISHIO, MAKI; YAMAMOTO, KOZO; OKUDA, TORU; KAWANO, KIMIO; NAKANISHI, NORIYUKI TMC-205 a New Transcriptional Up-Regulator of SV40 Promoter Produced by an Unidentified Fungus. Fermentation, Isolation, Physico-chemical Properties, Structure Determination and Biological Activities Journal of Antibiotics 2001 54 (8) 628-634. | ||
|---|---|---|---|
| DOI | 10.7164/antibiotics.54.628 | PMID | 11592499 |
SYNTHESES
| CITATION 1 | Gao Y; Osman S; Koide K Total Synthesis and Biological Studies of TMC-205 and Analogues as Anticancer Agents and Activators of SV40 Promoter. ACS Medicinal Chemistry Letters 2014 5 (8) 863-7. DOI: 10.1021/ml500025p PMID: 25147604 | ||
|---|---|---|---|
