Compounds
| ID | Spectrum Quality | Annotated Name |
|---|
COMPOUND NPA016792
PROPERTIES
| NPAID | NPA016792 |
|---|---|
| CLUSTER ID | 5706 |
| NODE ID | 4037 |
| NAME | FR901228 |
| FORMULA | C24H36N4O6S2 |
| MOLECULAR WEIGHT (Da) | 540.7080 |
| ACCURATE MASS (Da) | 540.2076 |
| ORIGIN ORGANISM TYPE | Bacterium |
| ORIGIN GENUS | Chromobacterium |
| ORIGIN SPECIES | violaceum No. 968 |
| InChIKey | OHRURASPPZQGQM-GCCNXGTGSA-N |
| InChI | InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1 |
| SMILES | C/C=C\1/C(=O)N[C@H](C(=O)O[C@H]\2CC(=O)N[C@@H](C(=O)N[C@H](CSSCC/C=C2)C(=O)N1)C(C)C)C(C)C |
ORIGINAL ISOLATION REFERENCE
| CITATION | Ueda; Nakajima; Hori; Fujita; Nishimura; Goto; Okuhara FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity Journal of Antibiotics 1994 47 (3) 301-310. | ||
|---|---|---|---|
| DOI | 10.7164/antibiotics.47.301 | PMID | 7513682 |
SYNTHESES
| CITATION 1 | Narita K; Kikuchi T; Watanabe K; Takizawa T; Oguchi T; Kudo K; Matsuhara K; Abe H; Yamori T; Yoshida M; Katoh T Total synthesis of the bicyclic depsipeptide HDAC inhibitors spiruchostatins A and B, 5''-epi-spiruchostatin B, FK228 (FR901228) and preliminary evaluation of their biological activity. Chemistry - A European Journal 2009 15 (42) 11174-11186. DOI: 10.1002/chem.200901552 PMID: 19760730 | ||
|---|---|---|---|
