Compounds
| ID | Spectrum Quality | Annotated Name |
|---|
COMPOUND NPA015806
PROPERTIES
| NPAID | NPA015806 |
|---|---|
| CLUSTER ID | 739 |
| NODE ID | 645 |
| NAME | FR901464 |
| FORMULA | C27H41NO8 |
| MOLECULAR WEIGHT (Da) | 507.6240 |
| ACCURATE MASS (Da) | 507.2832 |
| ORIGIN ORGANISM TYPE | Bacterium |
| ORIGIN GENUS | Pseudomonas |
| ORIGIN SPECIES | sp. No. 2663 |
| InChIKey | PJKVJJDQXZARCA-LBPFJSCKSA-N |
| InChI | InChI=1S/C27H41NO8/c1-16(8-11-23-25(31)27(15-33-27)14-26(6,32)36-23)7-10-22-17(2)13-21(19(4)35-22)28-24(30)12-9-18(3)34-20(5)29/h7-9,11-12,17-19,21-23,25,31-32H,10,13-15H2,1-6H3,(H,28,30)/b11-8+,12-9-,16-7+ |
| SMILES | CC1CC(C(OC1C/C=C(\C)/C=C/C2C(C3(CC(O2)(C)O)CO3)O)C)NC(=O)/C=C\C(C)OC(=O)C |
ORIGINAL ISOLATION REFERENCE
| CITATION | Nakajima; Sato; Fujita; Takase; Terano; Okuhara New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities Journal of Antibiotics 1996 49 (12) 1196-1203. | ||
|---|---|---|---|
| DOI | 10.7164/antibiotics.49.1196 | PMID | 9031664 |
SYNTHESES
| CITATION 1 | Thompson CF; Jamison TF; Jacobsen EN FR901464: total synthesis, proof of structure, and evaluation of synthetic analogues. Journal of the American Chemical Society 2001 123 (41) 9974-9983. DOI: 10.1021/ja016615t PMID: 11592876 | ||
|---|---|---|---|
| CITATION 2 | Albert BJ; Sivaramakrishnan A; Naka T; Koide K Total synthesis of FR901464, an antitumor agent that regulates the transcription of oncogenes and tumor suppressor genes. Journal of the American Chemical Society 2006 128 (9) 2792-2793. DOI: 10.1021/ja058216u PMID: 16506745 | ||
