Compounds
| ID | Spectrum Quality | Annotated Name |
|---|
COMPOUND NPA002361
PROPERTIES
| NPAID | NPA002361 |
|---|---|
| CLUSTER ID | 1414 |
| NODE ID | 390 |
| NAME | Chlorocyclinone A |
| FORMULA | C24H19ClO7 |
| MOLECULAR WEIGHT (Da) | 454.8620 |
| ACCURATE MASS (Da) | 454.0819 |
| ORIGIN ORGANISM TYPE | Bacterium |
| ORIGIN GENUS | Streptomyces |
| ORIGIN SPECIES | sp. (strain DSM 17045) |
| InChIKey | NFJVYTZFJNVKBA-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H19ClO7/c1-5-11-12(24(30)32-4)8-13-16(20(11)27)22(29)17-14(26)7-10-6-9(2)19(25)23(31-3)15(10)18(17)21(13)28/h6-8,26-27H,5H2,1-4H3 |
| SMILES | CCC1=C(C=C2C(=C1O)C(=O)C3=C(C2=O)C4=C(C(=C(C=C4C=C3O)C)Cl)OC)C(=O)OC |
ORIGINAL ISOLATION REFERENCE
| CITATION | Potterat, Olivier; Puder, Carsten; Wagner, Klaus; Bolek, Walter; Vettermann, Regine; Kauschke, Stefan G Chlorocyclinones A-D, chlorinated angucyclinones from Streptomyces sp. strongly antagonizing rosiglitazone-induced PPAR-gamma activation Journal of Natural Products 2007 70 (12) 1934-1938. | ||
|---|---|---|---|
| DOI | 10.1021/np070498j | PMID | 18044841 |
SYNTHESES
| CITATION 1 | Karmakar R; Mal D Total synthesis of chlorocyclinone A, a PPAR-γ antagonist. Journal of Organic Chemistry 2012 77 (22) 10235-10248. DOI: 10.1021/jo301712b PMID: 23078087 | ||
|---|---|---|---|
