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Compounds

COMPOUND NPA021254

STRUCTURE
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PROPERTIES
NPAID NPA021254
CLUSTER ID 24
NODE ID 23
NAME Kynapcin-12
FORMULA C22H18O8
MOLECULAR WEIGHT (Da) 410.3780
ACCURATE MASS (Da) 410.1002
ORIGIN ORGANISM TYPE Fungus
ORIGIN GENUS Polyozellus
ORIGIN SPECIES multiplex
InChIKey WOUMFZZOFGTIFS-UHFFFAOYSA-N
InChI InChI=1S/C22H18O8/c1-11(23)29-21-17(13-3-7-15(25)8-4-13)20(28)22(30-12(2)24)18(19(21)27)14-5-9-16(26)10-6-14/h3-10,25-28H,1-2H3
SMILES CC(=O)OC1=C(C(=C(C(=C1C2=CC=C(C=C2)O)O)OC(=O)C)C3=CC=C(C=C3)O)O
ORIGINAL ISOLATION REFERENCE
CITATION Lee HJ; Rhee IK; Lee KB; Yoo ID; Song KS Kynapcin-12, a New p-Terphenyl Derivative from Polyozellus multiplex. Inhibits Prolyl Endopeptidase Journal of Antibiotics 2000 53 (7) 714-719.
DOI 10.7164/antibiotics.53.714 PMID 10994814
ORIGINAL ISOLATION TAXONOMY
RANK NAME DB LINK NCBI
Domain Eukarya - 2759
Kingdom Fungi MycoBank 4751
Phylum Basidiomycota MycoBank 5204
Class Agaricomycetes MycoBank 155619
Order Thelephorales MycoBank 56487
Family Thelephoraceae MycoBank 56488
Genus Polyozellus MycoBank 281718
SYNTHESES
CITATION 1 Takahashi S; Yoshida A; Uesugi S; Hongo Y; Kimura K; Matsuoka K; Koshino H Structural revision of kynapcin-12 by total synthesis, and inhibitory activities against prolyl oligopeptidase and cancer cells. Bioorganic and Medicinal Chemistry Letters 2014 24 (15) 3373-6. DOI: 10.1016/j.bmcl.2014.05.091 PMID: 24948566
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